http://www.shtaixu.com
Home > Industry Information > Tianeptine is an antidepressant agent
Industry Information

Tianeptine is an antidepressant agent

2019-05-16

Depression is a debilitating chronic illness that affects around 350 million people worldwide. Current treatments, such as selective serotonin reuptake inhibitors, are not ideal because only a fraction of patients achieve remission. Tianeptine is an effective antidepressant with a previously unknown mechanism of action. We recently reported that tianeptine is a full agonist at the mu opioid receptor (MOR). Here we demonstrate that the acute and chronic antidepressant-like behavioral effects of tianeptine in mice require MOR. Interestingly, while tianeptine also produces many opiate-like behavioral effects such as analgesia and reward, it does not lead to tolerance or withdrawal. Furthermore, the primary metabolite of tianeptine (MC5), which has a longer half-life, mimics the behavioral effects of tianeptine in a MOR-dependent fashion. These results point to the possibility that MOR and its downstream signaling cascades may be novel targets for antidepressant drug development.
Previous: Apixaban Eliquis Next: Tianeptine Tianeptine sulphate Tianeptine Sodium

Related Products

Related Industry Information
Communicate with Supplier?Supplier
Mr. Vid Mr. Mr. Vid
What can I do for you?
Contact Supplier
黄,,,色,,小说在线看,丝袜美腿a片,av资源共享,情趣女黑色内裤,色视频线观看在线播放